Spironolactone

Spironolactone

CAS No.:52-01-7

EINECS:200-133-6

Purity:99% min

Quality:US

MOQ:10g

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Product Details

标签 Products Description.jpg

 It is a synthetic 17-lactone drug that is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat heart failure, ascites in patients with liver disease, low-renin hypertension, hypokalemia, secondary hyperaldosteronism (such as occurs with hepatic cirrhosis), and Conn's syndrome (primary hyperaldosteronism). On its own, spironolactone is only a weak diuretic because its effects target the distal nephron (collecting tubule), where urine volume can only be slightly modified; but it can be combined with other diuretics to increase efficacy. About one person in one hundred with hypertension has elevated levels of aldosterone; in these persons, the antihypertensive effect of spironolactone may exceed that of complex combined regimens of other antihypertensives. Due to its antiandrogen effect, it can also be used to treat hirsutism. It is also used for treating hair loss and acne in women, and can be used as a topical medication for treatment of male baldness. It is commonly used to treat symptoms of polycystic ovary syndrome (PCOS) such as excess facial hair and acne. It can also cause gynecomastia in males and should never be given with potassium supplementation for fear of the development of hyperkalemia.

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ITEMS

STANDARDS

RESULTS

Appearance (Ph.Eur.)

A white or yellowish-white powder

White powder

Solubility (Ph.Eur.)

Practically insoluble in water, soluble in ethanol (96%)

Complies

Identification

A. IR –spectrum (Ph.Eur.)

Meet the requirement

Complies

A. IR –spectrum (USP)

Meet the requirement

Complies

B. TLC (Ph.Eur.)

Meet the requirement

Complies

B. UV absorption (USP)

Meet the requirement

Complies

C. Colour reaction (Ph.Eur.)

Meet the requirement

Complies

C. Precipitate reaction (USP)

Meet the requirement

Complies

Specific optical rotation

-41°~-46°

-42.8°

(Ph.Eur.)

-41°~-45°

-42.9°

(USP)

 

 

Sulphated ash (Ph.Eur.)

≤0.1%

0.00%

Related substances (Ph.Eur.)

Impurity A

≤0.2%

N.D.

Impurity B

≤0.3%

N.D.

Impurity C

≤0.2%

N.D.

Impurity D

≤0.15%

N.D.

Impurity E

≤0.3%

N.D.

Impurity I

≤0.5%

0.05%

Any unspecified impurity

≤0.10%

Complies

Total

≤0.7%

0.13%

Ordinary impurities (USP)

≤2.0%

Complies

Free thiol compounds (Ph.Eur.)

≤0.05mL

Complies

Free mercapto compounds (USP)

≤0.10mL

Complies

Chromium (Ph.Eur.)

≤50ppm

Complies

Assay

97.5%~102.0%

100.90%

HPLC (Ph.Eur.)

97.5%~103.0%

99.60%

HPLC (USP)

 

 

Residual solvent (In-house)

≤3000ppm

90ppm

Methanol

≤720ppm

≤LOD (0.0046ppm)

Tetrahydrofuran

≤880ppm

≤LOD (0.23ppm)

DMF

 

 

Particle size (In-house)

95% ≤ 20 microns

Complies

Conclusion

Compiles with EP7/USP35


标签 Packaging.jpg

 Spironolactone
 25kg/Fiber Drum (35 cm* 53 cm), Double plastic bag inside;
 1Kg/Aluminum foil bag, with single plastic inside, and carton outside;
 And other package, or as your requirements.

包装图.jpg

 

标签 Shipping.jpg

 Spironolactone 

 Delivery: Sea/ Air Shipping & International Express  
 Shipping Time: 2-3 working days after payment  
 Storage: Kept away from strong light and heat.                                                                                    
 Shelf Life: 24 months

运输图.jpg


标签 FAQ.jpg

 Q1: Are you manufacturer or trading company for Spironolactone?
 A:We are trader with ISO22000,Kosher,Halal,HACCP certified over 10 years.


Q2:How can we guarantee you receive a good quality ?
 A: Our own factory comply to GMP standard and run with strict quality control,every batch of the product must be tested and ensure the quality before shipment.


Q3: What’s the delivery and shipping ?
 A:For sample,around 1-3days to be sent out upon receipt of payment by
 DHL,Fedex,TNT,UPS,EMS or SF.
 For small order, please expect 3-7days by DHL. FedEx,TNT,UPS EMS or SF.
 For bulk order, around 2 weeks to finish production from order confirmation,will be delivered by air or sea as customer requested.


Q4: Can I get some sample to test the quality?
 A: Of course you can, a 20g-30g free sample is available for you to test.


Q5: What’s the payment?
 A: We accept T/T,L/C,D/A,D/P,Western Union,Paypal.


Q6:What is your package and storage?
 A:25kg per paper drum with double layer poly bag inside.
 Store in cool and dry place, keep away from strong light and heat.


Q7:What is your return service policy?
 A: We offer a 45days guarantee on receipt of goods without any damage to packing. We will return your money if our products don’t conform to your approved quality.

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